Recent research has suggested that obesity may trigger inflammation in the nervous system. Wanting to further test those theories, Bertolazzi and colleagues compared DTI for dozens of teens and derived a measured called “fractional anisotropy” to correlate the condition of each subjects’ white matter and indicate increasing damage.
Their MRI analysis pinpointed dipping fractional anisotropy values in a bundle of nerve fibers that connects the left and right hemispheres of the brain, along with another region related to emotional control and reward.
Bertolazzi and colleagues noted that damage patterns also correlated with brain inflammation markers such as leptin, which is made by fat cells to regulate energy levels and fat stores. Some obese individuals’ brains do not respond to leptin, which can lead to overeating despite having adequate stores of fat.
The team next plans to conduct additional studies to figure out if this inflammation in obese teens’ brains is a consequence of structural changes in the brain.
This latest study was a continuation of another analysis presented at RSNA back in 2017, with the previous iteration focusing on changes in brain white matter in the amygdala, hippocampus, thalamus, cingulate gyrus, fornix, insula, putamen, orbital gyrus and bilateral hypothalamus. Those involved said finding such clues is crucial as the overweight youth population continues to grow.
“Childhood obesity has increased 10 to 40 percent in the last 10 years in most countries,” Bertolazzi said at the time. “If we are able to identify the brain changes associated with obesity, this DTI technique could be used to help prevent obesity and avoid the complications associated with the condition.”
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December 01, 2019 at 05:29PM
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Teen obesity may damage parts of the brain that regulates appetite, emotion - Radiology Business
"brain" - Google News
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